The phrase "lose mind" can have a number of synonyms. Some of these include "go insane," "lose one's sanity," "lose one's marbles," "lose one's wits," and "lose one's head." These synonyms all convey a sense of mental instability or madness, and can be used in a variety of contexts. For example, someone might say "I'm afraid I'm going to lose my mind if I have to keep working so many hours," or "After that accident, I felt like I was losing my head." Regardless of the specific synonym used, the phrase "lose mind" generally refers to a state of mental distress or confusion, and can be a signal that someone needs help or support.