Tsetse disease, also known as trypanosomiasis, is a debilitating illness caused by the bite of tsetse flies. These flies are prevalent in sub-Saharan Africa, particularly in areas with dense vegetation. Synonymous with African sleeping sickness, tsetse disease affects both humans and animals, causing fever, headaches, severe fatigue, joint pain, and eventually leading to neurological disorders if left untreated. The disease is caused by trypanosomes, a parasitic protozoan, transmitted by the tsetse fly. Despite ongoing efforts to control tsetse populations and develop effective treatments, tsetse disease remains a significant threat in affected regions, impacting both public health and agricultural productivity.