The antonyms of the word "uneasiest" can be varied, depending on the context in which it is used. For instance, if the word is referring to a task that is not easy to perform, its antonyms would include "easiest," "simplest," "most straightforward," or "effortless." If the word is used to describe a state of discomfort or anxiety, its antonyms would be "comfortable," "calm," "composed," or "at ease." In most cases, antonyms of "uneasiest" are associated with words that connote relaxation, simplicity, and effortlessness, which serve to contrast the idea of difficulty, complexity, and anxiety.