Fatigue disease is a medical condition characterized by extreme tiredness and weakness, often brought about by prolonged physical or mental activity. Fortunately, there are several synonyms for the term, including chronic fatigue syndrome, myalgic encephalomyelitis, and post-viral fatigue syndrome. These terms are used interchangeably by healthcare professionals to describe patients experiencing fatigue that lasts more than six months and is not relieved by rest. Despite the lack of a proven cure, various treatment options are available that may help alleviate symptoms and improve quality of life. These include medications, lifestyle changes, and cognitive behavioral therapy. Early diagnosis and appropriate management of this debilitating condition are essential to improve patient outcomes.