Miller-Dieker syndrome is a rare genetic disorder that affects brain development. Also known as lissencephaly type 1, this condition is caused by a mutation in the LIS1 gene on chromosome 17. The primary symptom of Miller-Dieker syndrome is a smooth brain surface, which can cause developmental delays, intellectual disability, and seizures. Other synonyms for Miller-Dieker syndrome include lissencephaly syndrome, Miller syndrome, and 17p13.3 deletion syndrome. Currently, there is no cure for Miller-Dieker syndrome, and treatment focuses on managing symptoms and providing support for affected individuals and their families. Early intervention and specialized care can improve outcomes for those with this condition.