Renal Cortical Necrosis is a severe condition that results from the death of renal cortical cells. There are several synonyms used to describe this condition, including kidney cortex necrosis, cortical renal necrosis, and cortical necrosis of the kidney. Another term for this condition is ischemic necrosis of the kidney, which refers to the reduction or complete lack of blood flow to the kidney's cortex causing the death of renal cells. Renal Cortical Necrosis can occur due to a range of underlying causes such as renal artery thrombosis or embolism, sepsis, or drug-induced toxicity. Early diagnosis and treatment are essential to prevent further damage to the kidney and save the patient's life.